Mit diesem Buch wird erstmals ein umfassendes und systematisches Referenzwerk zu Christian Wolff vorgelegt, das alle wichtigen Aspekte zu Leben und Werk des Philosophen behandelt. Das Handbuch ist von international renommierten Experten verfasst und behandelt neben der Biographie und der philosophiegeschichtlichen Rolle Wolffs sowohl sein philosophisches als auch sein naturwissenschaftlich-mathematisches Werk.

Taken together, Sections 145 and 63 of the Mental Health Act 1983 provide for treatment without consent of physical illness ancillary to the mental disorder with which a patient presents. On a daily basis, clinicians make both the decision that the Act’s authority can be applied to their patient’s case, and that it should be applied. But in the unusual circumstances where there is uncertainty as to the applicability of the MHA to the ancillary treatment of physical illness, the assistance (...) of a court may be sought. In so doing, the law may justify compulsion but never prescribes it; the clinician is presented with authority that he or she could use but is left to decide whether it should be employed. This paper explores how the clinical question is set before the court, and whether the distinction between symptom, manifestation and consequence is sufficiently understood. This has important consequences in the context of self-neglect and its close cousin self-harm: the question whether the relevant ailment was attributable to or exacerbated by neglect or self- inflicted harm will determine whether compulsion under the MHA is applicable; and furthermore, whether or not compulsion is clinically acceptable. No data are available. Not applicable. (shrink)

Chronic myeloid leukemia (CML) is a cancer of the hematopoietic system initiated by a single genetic mutation which results in the oncogenic fusion protein Bcr-Abl. Untreated, patients pass through different phases of the disease beginning with the rather asymptomatic chronic phase and ultimately culminating into blast crisis, an acute leukemia resembling phase with a very high mortality. Although many processes underlying the chronic phase are well understood, the exact mechanisms of disease progression to blast crisis are not yet revealed. In (...) this paper we develop a mathematical model of CML based on causal Bayesian networks in order to study possible disease progression mechanisms. Our results indicate that an increase of Bcr-Abl levels alone is not sufficient to explain the phenotype of blast crisis and that secondary changes such as additional mutations are necessary to explain disease progression and the poor therapy response of patients in blast crisis. (shrink)

Imagine that only the state can meet the need for housing but decides not to do so. Unsurprisingly, participants in a vignette experiment deem this scenario unjust. Hence, justice ratings increase when the living situation improves. To a lesser extent, this also holds beyond the need threshold, understood as the minimum amount necessary for a decent life. Surprisingly, however, the justice evaluation function is highly convex below this point. The resulting S-shaped curve is akin to the value function in prospect (...) theory, with the need threshold providing the point of reference and inflection. A control treatment without needs-information supports this interpretation. Needs-information furthermore compresses the perceived injustice of arbitrary inequality. As in prospect theory, such reference dependency suggests biases in judgment and decision making. A consequence may be that the lot of the poorest in society does not receive the attention it would otherwise get. (shrink)

The COVID-19 pandemic hit healthcare professionals (HCPs) hard, potentially leading to mental health deterioration. This longitudinal study investigated the 1-year evolution of psychological health of acute care HCPs during the COVID-19 pandemic and explored possible differences between high and low resilient HCPs. From April 2020 to April 2021, a convenience sample of 520 multinational HCPs completed an online survey every 3 months, up to five times. We used mixed linear models to examine the association between resilience and the variation of (...) COVID-19-related anxiety, depressiveness, perceived vulnerability, and psychological trauma symptomatology. We demonstrated “u-shaped” trajectories for all mental health symptoms. We also explored differences in the abovementioned variables between front-line and second-line acute care HCPs. In contrast to HCP.s with lower levels of resilience (-1SD), those with higher levels of resilience (+1SD) showed increased COVID-19 anxiety and perceived vulnerability over time. Front-line and second-line HCPs differed in their depressiveness and psychological trauma variation during the 1-year analysis. High and average resilient second-line HCPs showed steeper depressiveness increases with time than high and average resilient front-line HCPs. Acute care HCPs reported their most elevated clinical symptoms of depressiveness (5–7%) and psychological trauma symptomatology (26–46%) in April 2020. During the first year of the COVID-19 pandemic, second-line HCPs with more resilience showed a steeper worsening of their depressiveness than more resilient front-line HCPs. HCPs with low resilience may benefit from interventions at the beginning of a pandemic, whereas HCPs with high resilience might benefit from resilience-enhancing interventions at later phases.Trial RegistrationThe study protocol was pre-registered with the International Standard Randomised Controlled Trial Number (ISRCTN13694948) published (Fuchs et al., 2020). (shrink)

Following Smiley’s influential proposal, it has become standard practice to characterise notions of relative necessity in terms of simple strict conditionals. However, Humberstone and others have highlighted various flaws with Smiley’s now standard account of relative necessity. In their recent article, Hale and Leech propose a novel account of relative necessity designed to overcome the problems facing the standard account. Nevertheless, the current article argues that Hale & Leech’s account suffers from its own defects, some of which Hale & Leech (...) are aware of but underplay. To supplement this criticism, the article offers an alternative account of relative necessity which overcomes these defects. This alternative account is developed in a quantified modal propositional logic and is shown model-theoretically to meet several desiderata of an account of relative necessity. (shrink)

In Grundgesetze der Arithmetik, Frege tried to show that arithmetic is logical by giving gap-free proofs from what he took to be purely logical basic laws. But how do we come to judge these laws as true, and to recognize them as logical? The answer must involve giving an account of the apparent arguments Frege provides for his axioms. Following Sanford Shieh, I take these apparent arguments to instead be exhibitions: the exercise of a logical capacity in order to bring (...) us into a state of judgement. I provide an account of what sort of inferential capacities are at play in such exhibitions, and explain how they lead us to judge that Frege’s primitive laws are general and undeniable. I will also situate my account with respect to other rival interpretations, particularly the elucidatory interpretations of Joan Weiner and Thomas Ricketts. (shrink)

There are various well-known paradoxes of modal recombination. This paper offers a solution to a variety of such paradoxes in the form of a new conception of metaphysical modality. On the proposed conception, metaphysical modality exhibits a type of indefinite extensibility. Indeed, for any objective modality there will always be some further, broader objective modality; in other terms, modal space will always be open to expansion.

Here we present the personal perspectives of two authors on the important and unfortunately frequent scenario of ambulance clinicians facing a deceased individual and family members who do not wish them to attempt cardiopulmonary resuscitation. We examine the professional guidance and the protection provided to clinicians, which is not matched by guidance to protect family members. We look at the legal framework in which these scenarios are taking place, and the ethical issues which are presented. We consider the interaction between (...) ethics, clinical practice and the law, and offer suggested changes to policy and guidance which we believe will protect ambulance clinicians, relatives and the patient. (shrink)

In this empirical paper, Jay, Stone, Meksin, Merck, Gordon and Hirst examine whether jury deliberations, in which individuals collaboratively recall and discuss evidence of a trial, shape the jurors’ memories. In doing so, Jay and colleagues provide a highly ecologically valid baseline for future investigation into why, how and when selective recall either facilitates remembering or leads to forgetting during jury deliberations. In particular, Jay et al. explore the specific social and cognitive mechanisms that might lead to either memory facilitation (...) (RIFA – Retrieval Induced Facilitation) and forgetting (RIF ‐ Retrieval Induced Forgetting) during jury deliberation. (shrink)

Happy people often fail to elaborate on persuasive arguments, while people in sad moods tend to scrutinise messages in greater detail. According to some motivational accounts, however, happy people will elaborate a message if they believe it might maintain their positive mood. The present research extends this reasoning by demonstrating that happy people will elaborate arguments from message presenters that convey positive hedonic attributes (i.e., source likeability). In a pilot study, we show that happy people believe persuasive messages from a (...) likeable source will be mood maintaining. The results of Study 1 demonstrate that these expectancies have important message-processing implications. In Study 1, sad participants elaborated arguments from both likeable and dislikeable sources, while happy participants only elaborated arguments from a likeable source. Consistent with motivational explanation of these effects, in Study 2, happy participants elaborated arguments from a likeable source when not distracted, but used likeability as a heuristic when distracted with a cognitive-load manipulation. Implications of these results for understanding the effects of mood on processing strategy, limitations, and directions for future research are discussed. (shrink)

I present a novel argument against the non-contingency of identity. I first argue that the necessity of distinctness is intimately connected with numerous paradoxes of recombination. In particular, I argue that those who reject the necessity of distinctness have natural solutions to various paradoxes of recombination which have plagued the metaphysics of modality. Moreover, I argue that adding the necessity of distinctness to modest, paradox-free assumptions is sufficient to reinstate the paradoxes. Given that identity is non-contingent only if distinctness is (...) necessary, I suggest this constitutes new evidence against the non-contingency of identity. (shrink)

We have invented, discovered as we were shaping it, and set free from Marc Richir’s philosophy a fundamental element of comprehensibility regarding his phenomenology, which we have called ogkorhythm. The pertinence of this fundamental ogkorhythmic element is also to be found in its great problematic density, giving clarity to that which should be understood by space/time itself in contemporary French phenomenology and, in the context of this contribution, in the work of Max Loreau and Henri Maldiney. Our work mainly concerns (...) the analysis of notions of inherent volume in the work of the former and of rhythm in the work of the latter. Rhythm and volume whose meaning is, in part, derived in the light of ogkorhythm. (shrink)

Following David Lewis, Ted Sider has famously argued that unrestricted first-order quantification cannot be vague. His argument was intended as a type of reductio: its strategy was to show that the mere hypothesis of unrestricted quantifier vagueness collapses into the claim that unrestricted quantification is precise. However, this short article considers two natural reconstructions of the argument, and shows that each can be resisted. The theme will be that each reconstruction of the argument involves assumptions which advocates of vague quantification (...) have independent reason to reject. (shrink)

Par une analyse philosophique inédite, incluant des accents psychanalytique et esthétique, de la Petite Lettre sur les Mythes de Paul Valéry, nous montrons à l’œuvre comment une dimension proprement phantastique mouvante, loin de l’imagination avec ses images fixées, s’y décline jusqu’à développer une épopée phénoménologique ‘femmetastique’ entre amants épistoliers. Phénoménologie où nous entrons dans un véritable lieu mythique, voire fabuleux, d’une profusion transitionnelle et virtuelle inouïe, propice à l’inédit, à l’imprévu et, donc, à la création. On comprend mieux alors ce (...) que veut dire qu’ «il n’y a rien de si beau que ce qui n’existe pas», leçon valéryenne par excellence. (shrink)

Let Nomological Bound be the thesis that there is nothing objectively possible beyond what is physically possible. Nomological Bound has struck many as a live hypothesis. Nevertheless, in this article I provide a novel argument against it. Yet even though I claim that Nomological Bound is false, I argue that the boundaries of objective possibility can still be characterized intimately in terms of physical necessity. This is philosophically significant, for on a natural understanding it constitutes the powerful anti-sceptical result that (...) those who believe in physical necessity should not harbour any scepticism towards merely metaphysical possibilities. (shrink)

Somatic mutations arising in human skin cancers are heterogeneously distributed across the genome, meaning that certain genomic regions (e.g., heterochromatin or transcription factor binding sites) have much higher mutation densities than others. Regional variations in mutation rates are typically not a consequence of selection, as the vast majority of somatic mutations in skin cancers are passenger mutations that do not promote cell growth or transformation. Instead, variations in DNA repair activity, due to chromatin organization and transcription factor binding, have been (...) proposed to be a primary driver of mutational heterogeneity in melanoma. However, as discussed in this review here, recent studies indicate that chromatin organization and transcription factor binding also significantly modulate the rate at which UV lesions form in DNA. The authors propose that local variations in lesion susceptibility may be an important driver of mutational hotspots in melanoma and other skin cancers, particularly at binding sites for ETS transcription factors. (shrink)

Chisholm’s paradox serves as an important constraint on our modal theorising. For example, one lesson of the paradox is that widely accepted essentialist theses appear incompatible with metaphysical necessity obeying a logic that includes S4. However, this article cautions against treating Chisholm’s paradox in isolation, as a single line of reasoning. To this end, the article outlines two crucial morals about Chisholm’s paradox which situate the paradox within a broad family of paradoxes. Each moral places significant constraints on the paradox’s (...) solution space. In light of this perspective, the paper applies the two morals to a recently proposed solution to Chisholm’s Paradox by Benj Hellie, Murray and Wilson Oxford studies in metaphysics, Oxford University Press, Oxford, 2012). (shrink)

The Principle of Sufficient Reason must be justified dialectically: by showing the disastrous consequences of denying it. We formulate a version of the Principle that is restricted to basic natural facts, which entails the obtaining of at least one supernatural fact. Denying this principle results in extreme empirical skepticism. We consider six current theories of empirical knowledge, showing that on each account we cannot know that we have empirical knowledge unless we all have a priori knowledge of the PSR. We (...) consider objections based on Neo-Humeanism and the essentiality of origins, and we consider the possibility that we have empirical knowledge without knowing it. (shrink)

It is often presumed that anti-haecceitists are not committed to the identity of indiscernibles. However, I argue that anti-haecceitism implies a particularly strong thesis about when individuals are indiscernible which motivates the identity of indiscernibles. The argument is first sketched intuitively and then formalized in a system of higher-order modal logic.

In the metaphysics of modality, one finds a distinction between two families of modalities: the so-called ‘objective’, ‘real’ or ‘circumstantial’ modalities and the ‘non-objective’, ‘non-real’ or ‘non-circumstantial’ modalities. The guiding thought is that in some intuitive sense the former modalities pertain to contingency in worldly circumstance—how things could have genuinely otherwise been—whereas the latter do not. Moreover the distinction has acquired importance through attempts to elucidate the modality of metaphysical necessity by assigning it a distinctive role within the objective modalities. (...) In this paper I use the resources of higher-order modal logic to explore how one might systematize these ideas. I present a formal tension which shows that one natural way of systematizing them is unstable. And whilst I show that there are ways of stabilizing the guiding picture, even the best of them involves deeply non-trivial departures from how that picture is ordinarily understood. I conclude by revisiting the motivation for the underlying picture of modalities. (shrink)

We examine the role of need satisfaction in non-comparative justice ratings about endowments with goods. As normative approaches, we discuss utilitarianism, prioritarianism, and sufficientarianism. Using a vignette experiment, we show that a need context increases the prevalence of prioritarianistic and sufficientarianistic justice ratings, which leads to an ethically problematic sigmoid shape of the justice evaluation function.

Despite the frequency of stillbirths, the subsequent implications are overlooked and underappreciated. We present findings from comprehensive, systematic literature reviews, and new analyses of published and unpublished data, to establish the effect of stillbirth on parents, families, health-care providers, and societies worldwide. Data for direct costs of this event are sparse but suggest that a stillbirth needs more resources than a livebirth, both in the perinatal period and in additional surveillance during subsequent pregnancies. Indirect and intangible costs of stillbirth are (...) extensive and are usually met by families alone. This issue is particularly onerous for those with few resources. Negative effects, particularly on parental mental health, might be moderated by empathic attitudes of care providers and tailored interventions. The value of the baby, as well as the associated costs for parents, families, care providers, communities, and society, should be considered to prevent stillbirths and reduce associated morbidity. (shrink)

Contingentism is the view that it is contingent which things exist. Despite its plausibility, advocates of contingentism face a well-known ‘challenge’ to demonstrate that they can draw what appear to be intelligible modal distinctions (Williamson Modal Logic as Metaphysics. Oxford University Press, Oxford, 2013). In this article, I argue that if certain controversial modal principles fail, the challenge contingentists face becomes much more difficult. Whereas extant challenges concern contingentists’ inability to draw quite theoretical second-order modal distinctions, I present a challenge (...) which concerns contingentists’ inability to draw simpler first-order distinctions. This indicates that in certain modal settings there may well be significant first-order barriers to maintaining contingentism. (shrink)